-the first component of the pyruvate dehydrogenase complex, it is abbreviated as E1
This is a cutaway view of the complex, the E1 component is the yellow
Reaction Catalyzed
Pyruvate dehydrogenase performs decarboxylization of pyruvate to form acetyl-CoA, this is shown in the reaction above
Active Site
Pyruvate dehydrogenase has two sites, both provide magnesium ion and thiamine pyrophosphate (TPP) as cofactors. There is an alpha subunit and beta subunit of the E1 enzyme. The alpha binds a magnesium ion to a pyrophosphate fragment, and the beta binds pyrimidine fragment of TPP. This creates an active site.
Sources*Unable to determine: chemical formula, molecular weight, and rate information
Formula and Molecular weight aren't that hard to find...I'll give you a bit of a pass on the rate info!
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